Comparison of efficacy of selamectin, ivermectin and mebendazole for the control of gastrointestinal nematodes in rhesus macaque, China
Wang T, Yang GY, Yan HJ, Wang S, Bian Y, Chen AC, Bi FJ.
Abstract
An experiment was conducted to evaluate theefficacyofivermectinandmebendazolecompared withselamectinagainstgastrointestinalnematodesinrhesusmacaques. A total of 60rhesusmacaques (Macaca mulatta), which were all infected withgastrointestinalnematodes, were randomly assigned to three treatmentgroups(selamectin,ivermectinandmebendazole) and onecontrolgroup. Fecal samples for determining nematode egg counts were collected pre- and post-treatment. All treatments resulted in decrease in the number of eggs per gram (EPG) in the post-treatment sample compared with the pre-treatment sample. Reductions of mean egg counts from day -3 levels were 99.4% forselamectin, 99.2% forivermectinand 99.4% formebendazoleon trial day 11, respectively. However, no significant difference was found among treatmentgroups. According to the data demonstrating a similarefficacyinselamectin-,ivermectin- andmebendazole-treatedrhesusmacaques, it was effective and convenient to apply eitherselamectinandivermectinormebendazolein rotation on the local conditions.
Copyright © 2008 Elsevier B.V. All rights reserved.
Vet Parasitol.2008 May 6;153(1-2):121-5. doi: 10.1016/j.vetpar.2008.01.012. Epub 2008 Jan 17.
